Peer-reviewed veterinary case report
How vasopressin raises blood pressure in dogs with severe bleeding
By Yoo, Jong-Hyun et al.·Published in The Journal of veterinary medical science·2006·Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: Hemodynamic characteristics of vasopressin in dogs with severe hemorrhagic shock.
- Species:
- dog
Plain-English summary
Six dogs in severe hemorrhagic shock were treated with either vasopressin or epinephrine after receiving fluids to help stabilize their blood pressure. The dogs given vasopressin showed a significant increase in diastolic blood pressure within five minutes, while those receiving epinephrine had only a temporary increase. Vasopressin provided a more stable and longer-lasting effect on blood pressure compared to epinephrine. The study suggests that vasopressin may be a safer and more effective option for treating severe hemorrhagic shock in dogs.
People also search for: dog hemorrhagic shock treatment · vasopressin for dogs · epinephrine vs vasopressin in dogs
Abstract
The effect of vasopressin was compared with that of the established vasopressor epinephrine in experimentally induced hemorrhagic shock. After rapid crystalloid resuscitation in a ratio of three volumes of 0.9% saline to one volume of blood (3:1 crystalloid resuscitation), six dogs were given 0.4 IU/kg vasopressin and another six dogs were given 0.1 mg/kg epinephrine. Five dogs in the control group were given fluid resuscitation in the same manner as above without administration of any drugs. Administration of vasopressin increased diastolic arterial pressure (DAP) from 45.0 +/- 4.9 to 91.2 +/- 9.6 mmHg within 5 min, compared with epinephrine from 46 +/- 4.0 to 51.8 +/- 7.7, and control from 47.3 +/- 7.5 to 46.3 +/- 7.3. Systolic arterial pressure (SAP) did not increase significantly following vasopressin compared with epinephrine and control group. Results of DAP and systemic vascular resistance index (SVRI) suggested that vasopressin administration was vasoconstrictive after fluid resuscitation in decompensatory hemorrhagic shock in dogs, whereas epinephrine did not compared with control. In addition, epinephrine did not affect the cardiac index (CI) and SVRI, while a significant decrease in CI and increase in SVRI were observed in vasopressin group. The pressor effect of epinephrine in the vascular system was abrupt and only lasted a short period of time (within 5 min), while that of vasopressin was steady and lasted for more than 1 hr, especially regard to in DAP. When compared with epinephrine, vasopressin can be a more effective and safer choice in patients with severe hemorrhagic shock.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17019067/