Peer-reviewed veterinary case report
Cat with blood disorder linked to multiple myeloma cancer
By Dunbar, Mark D. & Lyles, Sarah·Published in Veterinary Clinical Pathology·2012·Department of Physiological Sciences University of Florida Gainesville FL USA, United States·View original on Crossref →
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Original publication title: Hemophagocytic syndrome in a cat with multiple myeloma
- Species:
- cat
Plain-English summary
An 11-year-old male Domestic Medium Hair cat was brought to the vet with a two-week history of upper respiratory symptoms and abnormal blood test results. The cat had anemia and high levels of certain proteins in the blood, but physical exams showed no major issues. Tests revealed that the cat had multiple myeloma, a type of cancer affecting plasma cells, along with a rare condition called hemophagocytic syndrome, where the body mistakenly attacks its own blood cells. This case is notable as it's the first report of this syndrome linked to cancer in a cat.
People also search for: cat upper respiratory infection · cat anemia treatment · multiple myeloma in cats · hemophagocytic syndrome in cats
Abstract
AbstractAn 11‐year‐old, castrated male, Domestic Medium Hair cat was presented to the University of Florida Small Animal Hospital with a 2‐week history of upper respiratory infection and increased serum globulins, as reported by the referring veterinarian. Physical examination was unremarkable other than melanosis of the left iris, with no evidence of ocular, nasal, or respiratory disease. Laboratory abnormalities included moderate nonregenerative anemia, mild leukopenia, mild hyperfibrinogenemia, severe hyperglobulinemia, mild hypoalbuminemia, and hypocholesterolemia. Abdominal radiographs and ultrasonographic examination revealed mild splenomegaly with no other abnormalities. Thoracic radiographs revealed no abnormalities. Cytologic evaluation of fine‐needle aspirates from the spleen, liver, and bone marrow revealed numerous plasma cells and many vacuolated macrophages exhibiting marked phagocytosis of mature erythrocytes and platelets, occasionally metarubricytes and leukocytes, and rarely plasma cells. The cytologic interpretation was multiple myeloma and associated hemophagocytic syndrome (HPS). Serum protein electrophoresis revealed a monoclonal gammopathy, providing further evidence for a multiple myeloma. To the authors' knowledge, this is the first report ofHPSsecondary to neoplasia in a cat.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vcp.12015