Peer-reviewed veterinary case report
Hemophilia B causing bleeding in German Shepherd puppies
By Feldman, D G et al.·Published in Journal of the American Veterinary Medical Association·1995·California Animal Hospital, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Hemophilia B (factor IX deficiency) in a family of German shepherd dogs.
- Species:
- dog
Plain-English summary
Three male German Shepherd puppies developed severe bleeding problems after vaccinations, leading to the discovery of hemophilia B (a condition where the blood doesn't clot properly due to a lack of factor IX). Blood tests showed that two of the pups had significantly prolonged clotting times, confirming the deficiency. Unfortunately, two of the pups had to be euthanized due to ongoing bleeding issues, while the third pup is still alive but needs regular blood transfusions to manage his condition. This family of dogs has a history of bleeding disorders, suggesting a genetic link.
People also search for: German Shepherd puppy bleeding after vaccination · hemophilia B in dogs · blood transfusion for dogs with bleeding disorders
Abstract
Three male German Shepherd Dog pups were treated for vaccination-induced hematomas. Coagulation tests in 2 of these pups revealed markedly prolonged activated partial thromboplastin times, whereas specific coagulation factor tests revealed severe deficiency of factor IX activity. Investigation of the pedigree supported a sex-linked pattern of inheritance and a distant relationship to a pup found to have hemophilia B 7 years earlier. Dogs in the pedigree had variable manifestations of bleeding, including hematomas, deep muscle bleeding, profuse bloody diarrhea, and sudden neonatal deaths. von Willebrand's disease was concurrently detected in several dogs in the pedigree, and may have contributed to the bleeding tendency in some dogs. Medical management of 2 of the 3 pups included transfusion of fresh whole blood, canine fresh-frozen plasma, and canine plasma cryosupernatant, as indicated, and cage rest. Two pups were euthanatized because of the severity of recurrent bleeding episodes. A third dog remains alive, but requires periodic infusions of blood product to maintain hemostasis.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/7790304/