Peer-reviewed veterinary case report
Dog with blood in urine after carboplatin chemo treatment
By MacDonald, Valerie & Dickinson, Ryan·Published in Journal of the American Animal Hospital Association·2014·Department of Small Animal Clinical Sciences, Canada·View original on PubMed →
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Original publication title: Hemorrhagic cystitis in a dog receiving carboplatin.
- Species:
- dog
Plain-English summary
An 8-year-old male Labrador mix with bone cancer developed blood in his urine, frequent urination, and difficulty urinating after his third round of chemotherapy with carboplatin. The vet diagnosed him with hemorrhagic cystitis (inflammation of the bladder with bleeding) and decided to stop the carboplatin, switching to a different chemotherapy drug called doxorubicin. The dog was also given meloxicam for pain relief, and his symptoms improved over the next four weeks.
People also search for: dog blood in urine after chemotherapy · Labrador retriever bladder inflammation treatment · doxorubicin for dog cancer
Abstract
An 8 yr old castrated male Labrador retriever mixed-breed dog with osteosarcoma (OSA) of the left proximal humerus receiving carboplatin presented 10 days after the third chemotherapy treatment with hematuria, stranguria, and pollakiuria. A presumptive diagnosis of hemorrhagic cystitis was made based on clinical signs, urinalysis, and cytologic analysis of a traumatic catheterization sample. Carboplatin was removed from the chemotherapy treatment plan and was substituted with doxorubicin. The dog was treated with meloxicam for pain, and the cystitis signs subsided over a period of 4 wk. Carboplatin is commonly used as adjuvant chemotherapy for dogs with OSA following amputation and is not known to cause hematuria in dogs, although there are reports of this occurring in humans. To the authors' knowledge, there are no reports in the veterinary literature of this toxicity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24216493/