Peer-reviewed veterinary case report
Blood clotting problems in dogs with carcinoma tumors
By Vilar Saavedra, Paulo et al.·Published in Veterinary journal (London, England : 1997)·2011·Department of Veterinary Clinical Sciences and Veterinary Medical Center, United States·View original on PubMed →
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Original publication title: Hemostatic abnormalities in dogs with carcinoma: a thromboelastographic characterization of hypercoagulability.
- Species:
- dog
Plain-English summary
A group of 32 dogs with cancer (carcinoma) showed signs of abnormal blood clotting, which can lead to serious health issues. Tests revealed that these dogs had higher levels of certain blood components, indicating they were more prone to forming clots. Specifically, nearly half of the dogs had a condition called hypercoagulability, which means their blood was clotting too easily, while a third had high fibrinogen levels, a protein involved in clot formation. Monitoring these blood parameters can help veterinarians manage the risks associated with cancer in dogs.
People also search for: dog cancer blood clotting · hypercoagulability in dogs · dog cancer treatment options
Abstract
Hemostatic abnormalities were investigated in 32 dogs with carcinoma and 19 age-matched healthy dogs. Thromboelastography, hemostasis profile (i.e. prothrombin time [PT], activated partial thromboplastin time [aPTT], fibrinogen concentration), platelet count (PLT), thrombin-antithrombin complexes (TAT), and plasminogen activator inhibitor-1 (PAI-1) activity were evaluated. Dogs with carcinomas had faster thrombus generation (TEG(TG), a mathematic value obtained from the first derivate of the thromboelastographic tracing; 834.8±91.1 vs. 707.8±75.8mm/min; mean±SD), increased fibrinogen concentration (276 vs. 151mg/dL), and PLT (425 vs. 324U×10(9)/L), but had decreased PAI-1 activity (15.7 vs. 26.2IU/mL).The most common hemostatic abnormalities found in carcinoma dogs were hypercoagulability (TEG(TG)>mean+2 SD of healthy dogs) and thrombocytosis (PLT>424×10(9)U/L) in 46% of cases, and hyperfibrinogenemia (fibrinogen >384mg/dL) in 32% of cases. Disseminated intravascular coagulation was uncommon and the extent of disease was not correlated with hypercoagulability. TEG(TG) showed good correlation with fibrinogen (r=0.80) and hyperfibrinogenemia seems to be a main factor of the hypercoagulable state in carcinoma dogs. In conclusion, TEG(TG) is a valid parameter to diagnose hypercoagulability.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21454111/