Peer-reviewed veterinary case report
Copper and other minerals in dogs with liver cancer
By Harro, Cailin C et al.·Published in Journal of veterinary internal medicine·2019·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Hepatic copper and other trace mineral concentrations in dogs with hepatocellular carcinoma.
- Species:
- dog
Plain-English summary
A study looked at liver samples from dogs with hepatocellular carcinoma (HCC), a common liver tumor, to see if there were any differences in trace minerals like copper, zinc, iron, and selenium. The researchers found that dogs with HCC had higher levels of copper in their non-cancerous liver tissue compared to healthy dogs. However, the levels of these minerals were lower in the cancerous tissue itself. This suggests that copper buildup and other mineral imbalances might play a role in the development of liver tumors in dogs.
People also search for: dog liver cancer symptoms · high copper levels in dogs · liver tumor treatment in dogs
Abstract
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary liver tumor in dogs. Abnormalities in hepatic copper, iron, zinc, and selenium concentrations increase risk for HCC development in other species, but trace mineral concentrations have not been evaluated in dogs with HCC. OBJECTIVES: To investigate hepatic trace mineral concentrations in dogs with HCC. ANIMALS: Archived liver specimens from 85 dogs with HCC and 85 control dogs. METHODS: Retrospective case-control study. A histopathology database was searched to identify dogs with HCC (test population) and an age-matched control population. Demographic information was retrieved, and H&E and rhodanine stained slides were reviewed for all cases. Copper, iron, zinc, and selenium concentrations were determined in noncancerous liver tissues (test and control population) and in HCC tissues (test population) using inductively coupled plasma mass spectrometry. RESULTS: Hepatic copper concentrations (non-neoplastic hepatic tissue) were greater in test population dogs (median, IQR; 294.9 μg/g, 233.5-475.9 μg/g) than in control dogs (202.8 μg/g, 135.0-295.3 μg/g; P < .001). Hepatic zinc concentrations in test (132.1 μg/g,108.6-163.2 μg/g) and control dogs (151.5 μg/g, 117.1-184.5 μg/g) also were different (P = .03). Within test population dogs, all trace mineral concentrations were decreased in the HCC tissue as compared to the non-neoplastic hepatic tissue (all P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Hepatic copper accumulation and other abnormalities in hepatic trace mineral concentrations could be involved in the pathogenesis of HCC in some dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31493348/