Peer-reviewed veterinary case report
Rare liver myoepithelial cancer found in an 11-year-old dog
By Tsuji, Yuka et al.·Published in Veterinary pathology·2019·Osaka Prefecture University, Japan·View original on PubMed →
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Original publication title: Hepatic Myoepithelial Carcinoma in a Dog: Immunohistochemical Comparison With Other Canine Hepatic Carcinomas.
- Species:
- dog
Plain-English summary
An 11-year-old female miniature Dachshund was brought to the vet after a solid, soft, gray mass was found on her liver. Tests showed that the mass was a type of cancer called myoepithelial carcinoma, which is rare in dogs. The vet used special staining techniques to confirm the diagnosis and to compare it with other liver tumors in dogs. Unfortunately, the specific treatment details and outcome for this dog were not provided, but early detection and treatment are crucial for managing any type of cancer.
People also search for: dog liver cancer symptoms · Dachshund liver tumor treatment · myoepithelial carcinoma in dogs
Abstract
An 11-year-old female miniature Dachshund dog presented with a solid, soft, gray mass on the hepatic lateral left lobe. Histologically, the mass consisted of neoplastic proliferation of cells with round nuclei and eosinophilic and vacuolated cytoplasm arranged in alveolar, trabecular, and solid patterns. Immunohistochemically, the neoplastic cells were positive for pancytokeratin (CK AE1/AE3), CK5, CK14, vimentin, Sox9, and myoepithelial markers (α-smooth muscle actin, p63, and calponin). The morphological and immunohistochemical findings indicated a diagnosis of myoepithelial carcinoma. We conducted immunohistochemical studies on other representative canine hepatic tumors. Although the myoepithelial phenotype was not observed in the hepatocellular carcinoma, some tumor cells in cholangiocarcinoma showed immunohistochemical features of myoepithelium, suggesting that some neoplastic cells in cholangiocarcinoma may have the potential to differentiate into myoepithelial cells. To our knowledge, this is the first report in veterinary medicine of a hepatic carcinoma with a myoepithelial phenotype.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31170892/