Peer-reviewed veterinary case report
Dog given zonisamide for seizures developed severe liver cell death
By Takami, Yuki et al.·Published in The Journal of veterinary medical science·2020·Osaka Prefecture University, Japan·View original on PubMed →
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Original publication title: Hepatocellular necrosis with prominent regenerative reactions in a zonisamide administrated dog.
- Species:
- dog
Plain-English summary
A 16-year-old neutered male Miniature Dachshund was brought to the vet after experiencing vomiting, loss of appetite, and diarrhea. Blood tests showed a significant increase in liver enzymes, indicating liver damage. Unfortunately, the dog passed away six days later, and a necropsy revealed severe liver damage likely caused by long-term use of the medication zonisamide, which was given for seizures. The findings suggested that the liver was not only damaged but also trying to regenerate, indicating chronic injury.
People also search for: dog vomiting and diarrhea · Miniature Dachshund liver problems · zonisamide side effects in dogs
Abstract
A 16 years old neutered male Miniature Dachshund with 1-year history of repetitive administration of zonisamide for treatment of epileptic seizure was presented for vomiting, anorexia and diarrhea. Serum biochemistry showed a markedly elevated ALP level. The dog died 6 days after the presentation and a necropsy was performed. Histopathologically, random, focal to extensive necrosis, formation of regenerative hepatocellular nodules surrounded by fibrous septa and proliferation of bile ducts were seen in the liver. From these findings, the hepatic lesion was diagnosed as hepatocellular necrosis with prominent regenerative reactions due to the chronic persistent liver injury. Hepatic lesions were considered to be induced by zonisamide, based on the history of continuous administration, and clinical and histopathological findings.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32249255/