Peer-reviewed veterinary case report
Siberian Husky died from liver damage after carprofen and meloxicam
By Nakagawa, Kiyoshi et al.·Published in The Journal of veterinary medical science·2005·Nakagawa Animal Hospital, Japan·View original on PubMed →
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Original publication title: Hepatocellular toxicosis associated with the alternate administration of carprofen and meloxicam in a siberian husky.
- Species:
- dog
Plain-English summary
A 4-year-old female Siberian Husky became very sick after receiving a combination of pain medications, carprofen and meloxicam, for a recurring anal sac issue. After 13 days of treatment with carprofen and another antibiotic, the dog showed no improvement. Following surgery, she received meloxicam, but her liver enzymes were high, indicating liver stress. The next day, she stopped eating and started vomiting. Despite treatment, she did not recover and sadly passed away two days later. A postmortem exam showed severe liver damage likely caused by the medications.
People also search for: Siberian Husky vomiting after medication · carprofen side effects in dogs · liver problems in dogs after surgery
Abstract
A 4-year-old female Siberian Husky was diagnosed with pyogranulomatous steatitis at the site of a recurrence of left anal sac rupture (day 1). Carprofen and orbifloxacin were given for 13 days without improvement. A single dose of meloxicam was administered prior to surgical resection of the anal sac, and based on elevated liver enzyme activity, liver supportive therapy was initiated. The dog received carprofen and orbifloxacin orally on the evening of day 14. The dog became anorectic the following morning, and began vomiting. Despite supportive therapy, the dog was unresponsive to treatment and died on day 16. Postmortem examination revealed severe vacuolar change and acute necrosis of hepatocytes consistent with carprofen and meloxicam induced-toxicosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16276063/