Peer-reviewed veterinary case report
Young dog with liver and pancreas nerve tumor causing weight loss
By R. Zafra et al.·Published in Veterinární Medicína·2011·Faculty of Veterinary Medicine, University of Cordoba, Spain, CZ·View original on DOAJ →
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Original publication title: Hepatopancreatic ganglioneuroma in a young dog: a case report
- Species:
- dog
Plain-English summary
A 7-month-old dog was brought in for progressive weight loss, not eating, and abdominal pain. During a laparoscopic exam, the vet found several small whitish nodules around the pancreas and bile duct. Unfortunately, due to the poor prognosis, the dog was euthanized, and a necropsy revealed that these nodules were a type of tumor called ganglioneuroma. This case is unusual because most ganglioneuromas in dogs occur in the gastrointestinal tract, and this dog was quite young for such a diagnosis.
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Abstract
The clinical, pathological and immunohistochemical features of a hepatobiliary and pancreatic ganglioneuroma in a seven-month-old dog are described. The dog presented progressive weight loss, anorexia and abdominal pain. At laparoscopic examination numerous whitish nodules ranging from 0.5 to 1 cm in diameter were found in the peripancreatic tissues, the bile duct system and perihepatic tissues. Due to poor prognosis the dog was euthanized and necropsy was conducted. Tumour nodules were not noted in the other examined abdominal organs. Microscopically, the nodules were composed of large, well differentiated neurons embedded in an abundant stroma of nerve fibres and connective fibrous tissue. Through immunohistochemistry analysis, neurons were found to express neurofilaments and did not express S-100 protein. The histopathological and immunohistochemical features were consistent with a diagnosis of ganglioneuroma. This case is atypical as the majority of reported canine ganglioneuromas involve the gastrointestinal tract. The early age of the dog is also considered to be atypical for this tumour.
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Search related cases →Original publication on DOAJ: https://doi.org/10.17221/1578-VETMED