Peer-reviewed veterinary case report
Hereditary nasal skin disease in Labrador Retrievers
By Pagé, Nadia et al.·Published in Veterinary dermatology·2003·Veterinary Teaching Hospital, Canada·View original on PubMed →
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Original publication title: Hereditary nasal parakeratosis in Labrador Retrievers.
- Species:
- dog
Plain-English summary
A group of Labrador Retrievers developed crusty, scaly lesions on their noses starting between 6 and 12 months of age, which was linked to a hereditary condition. Despite trying various treatments like zinc, antibiotics, and vitamin A, these did not help. However, some dogs showed improvement when treated with topical vitamin E, petroleum jelly, and propylene glycol. This suggests that while the condition is inherited and challenging to treat, certain topical treatments can provide relief for affected dogs.
People also search for: Labrador Retriever nose lesions · dog skin problems treatment · hereditary skin condition in dogs · vitamin E for dog skin issues
Abstract
Hereditary nasal dermatitis is reported in 14 Labrador Retrievers and 4 Labrador Retriever crosses. This appears to be a newly described inherited disorder for which an autosomal recessive mode of inheritance is suspected. The lesions were first noted between 6 and 12 months of age. Histopathological analysis revealed parakeratotic hyperkeratosis, often with marked multifocal accumulation of proteinaceous fluid between keratinocytes within the stratum corneum and superficial stratum spinosum. There was also a sub-basal lymphoplasmacytic infiltration within the superficial dermis. Immunohistochemistry staining for IgG (n = 4), distemper and papillomaviruses (n = 4) were negative, as were serum antinuclear antibody serology (n = 4) and fungal culture (n = 7). Electron microscopy revealed an altered cornification process: retention of nuclear chromatin, absence of lamellar bodies and marked intercellular oedema. Dogs did not respond to oral administration of zinc methionin (n = 3), cephalexin (n = 4), vitamin A alcohol (n = 1) or topical tretinoin (n = 1). Improvement of the lesions was obtained with topical vitamin E (n = 2), petroleum jelly (n = 2), and propylene glycol (n = 5).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12662268/