Peer-reviewed veterinary case report
Necrotizing meningoencephalitis in Pugs is inherited and fatal by 19
By Greer, Kimberly A et al.·Published in Research in veterinary science·2009·Indiana University East, United States·View original on PubMed →
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Original publication title: Heritability and transmission analysis of necrotizing meningoencephalitis in the Pug.
- Species:
- dog
Plain-English summary
A group of Pugs diagnosed with necrotizing meningoencephalitis (NME), a severe brain disease, showed that this condition is likely inherited. The average age when symptoms appeared was around 19 months, and sadly, most affected dogs only survived about 23 days after diagnosis. Tests for common viruses that could cause the disease came back negative, suggesting that genetics play a significant role in this illness. This study highlights the importance of understanding the hereditary nature of NME in Pugs, which could help owners and breeders make informed decisions.
People also search for: pug brain disease symptoms · necrotizing meningoencephalitis pug · pug genetic disorders · pug health issues · pug lifespan with NME
Abstract
Necrotizing meningoencephalitis (NME) in the Pug is an invariably fatal disease with an early age of onset whose cause remains unknown. Breed predilection strongly suggests genetic component(s), and viral etiology proves negative in studied cases. The current study was undertaken as the first analysis of the heritable component(s) involved in NME in the Pug. Complete medical records, individual characteristics, and pedigree information were collected for 58 affected dogs with data pertaining to 4698 dogs analyzed. A high inbreeding coefficient with differences across gender and significant differences across coat color classes and variable expression was evident. Median onset age was 19months and median survival time 23days. Screening for herpes-, adeno-, and parvoviruses was negative. The data demonstrate a strong familial inheritance of NME in the Pug. This investigation provides parameters of disease from the largest Pug NME cohort analyzed to date and offers evidence of previously unrecognized familial inheritance.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19014875/