Peer-reviewed veterinary case report
Different c-kit gene mutations found in multiple mast cell tumors
By Amagai, Y et al.·Published in The Journal of small animal practice·2013·Graduate School of Bio-Applications and System Engineering, Japan·View original on PubMed →
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Original publication title: Heterogeneity of internal tandem duplications in the c-kit of dogs with multiple mast cell tumours.
- Species:
- dog
Plain-English summary
A 7-year-old mixed-breed dog was diagnosed with multiple mast cell tumors, which are a type of skin cancer. Genetic testing showed that the tumors had different mutations in the c-kit gene, suggesting that each tumor developed independently rather than from a single source. This finding highlights the complexity of mast cell tumors and indicates that treatment may need to be tailored based on the specific mutations present. The study suggests that veterinarians should consider genetic testing of multiple tumor sites to better predict how the dog might respond to treatments like KIT inhibitors.
People also search for: dog mast cell tumor treatment · mixed-breed dog skin cancer · c-kit mutations in dogs
Abstract
Mast cell tumours are one of the most common neoplasms in dogs. Mutations in the proto-oncogene c-kit, especially internal tandem duplications of exon 11, are considered to play a crucial role in mast cell tumourigenesis. In this report, two cases that suffered from multiple mast cell tumours containing an internal tandem duplication in the primary lesion but not in the secondary lesions are described. This finding indicates the existence of heterogenous c-kit gene mutations in each site of multiple mast cell tumours. Additionally, these results raise the possibility that the contribution of internal tandem duplications in the malignant transformation of mast cells is quite limited. It is proposed that, for clinicians, genetic analysis of several regions of multiple mast cell tumours is necessary for predicting prognosis and tumour response to KIT inhibitors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23614673/