Peer-reviewed veterinary case report
Heterotopic inputs facilitate poststimulus afterdischarges of spinal WDR neurons in rats with chronic nerve constriction.
- Journal:
- Brain research
- Year:
- 2006
- Authors:
- Sotgiu, Maria Luisa et al.
- Affiliation:
- Istituto di Bioimmagini e Fisiologia Molecolare · Italy
- Species:
- rodent
Abstract
Heterotopic inputs activate spinal wide dynamic range (WDR) neurons in rats with chronic constriction of one sciatic nerve (CCI rats). A possible contribution from these inputs, to long-lasting afterdischarges (ADs) of noxious evoked responses, was investigated during reversible input blockade from adjacent saphenous nerve and contralateral peripheral nerve territories. The results show significant AD reduction or suppression, indicating that heterotopic afferences contribute to mechanisms underlying prolonged ADs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16797491/