Peer-reviewed veterinary case report
High but not low frequency stimulation of both the globus pallidus and the entopeduncular nucleus reduces 'compulsive' lever-pressing in rats.
- Journal:
- Behavioural brain research
- Year:
- 2011
- Authors:
- Klavir, Oded et al.
- Affiliation:
- Department of Psychology
- Species:
- rodent
Abstract
The anti-compulsive effects of high and low frequency stimulation (LFS, HFS) of the entopeduncular nucleus and globus pallidus (the rat's equivalent, respectively, of the primate's internal and external segments of the globus pallidus) were assessed in the signal attenuation rat model of obsessive-compulsive disorder (OCD). HFS, but not LFS, of the two nuclei exerted an anti-compulsive effect, suggesting that HFS of either segment of the globus pallidus may provide an additional therapeutic strategy for OCD.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20654653/