Peer-reviewed veterinary case report
Dog with aggressive skin mast cell tumor spreading to chest and heart
By Yale, Andrew D et al.·Published in Journal of comparative pathology·2020·Royal Veterinary College, United Kingdom·View original on PubMed →
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Original publication title: High-Grade Cutaneous Mast Cell Tumour with Widespread Intrathoracic Metastasis and Neoplastic Pericardial Effusion in a Dog.
- Species:
- dog
Plain-English summary
An 8-year-old neutered male French Bulldog was brought to the vet after experiencing intermittent vomiting, a decreased appetite, and the sudden appearance of multiple lumps on his head and neck over two days. The vet found fluid around the heart and lungs, and tests revealed that one of the lumps was a high-grade mast cell tumor, which had spread to the heart and other areas. Unfortunately, despite the diagnosis, the dog had widespread cancer that affected his heart and surrounding tissues. This case highlights the serious nature of mast cell tumors in dogs and their potential to spread aggressively.
People also search for: dog vomiting and lumps · French Bulldog mast cell tumor treatment · dog heart cancer symptoms
Abstract
An 8-year-old neutered male French Bulldog was presented with a 2-day history of intermittent vomiting, reduced appetite and recent rapid development of multiple cutaneous masses over the head and neck regions. On presentation, the patient had a moderate volume of pericardial and bilateral pleural effusion. Echocardiography demonstrated irregular, heterogeneous thickening of the walls of the right ventricle and right atrium, consistent with infiltrative intramyocardial disease. Cytological examination of fine needle aspirates from one of the cutaneous masses confirmed a mast cell tumour. Pericardial fluid analysis revealed a haemorrhagic neoplastic effusion due to mast cell neoplasia. Histopathological and immunohistochemical examination of tissues obtained post mortem confirmed a high-grade cutaneous mast cell tumour with metastasis to the heart, pericardium, mediastinum and spleen. No metastatic disease was present in the submandibular lymph nodes or liver. Immunohistochemistry demonstrated KIT staining pattern 2. There was strong nuclear Ki67 labelling in an average of 65.0 cells per grid and an average of three positive AgNORs per nucleus in neoplastic cells. Polymerase chain reaction for the activating duplication mutation in exons 8 and 11 of c-Kit were negative. To the authors' knowledge, this is the first report of a canine cutaneous mast cell tumour associated with neoplastic pericardial effusion and widespread intrathoracic metastasis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33222871/