Peer-reviewed veterinary case report
Fluoroquinolone and methicillin resistant Staphylococcus in dog skin
By Yoo, Jong-Hyun et al.·Published in Journal of microbiology and biotechnology·2010·BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: High prevalence of Fluoroquinolone- and Methicillin-resistant Staphylococcus pseudintermedius isolates from canine pyoderma and otitis externa in veterinary teaching hospital.
- Species:
- dog
Plain-English summary
A study found that a significant number of Staphylococcus pseudintermedius bacteria, which can cause skin infections (pyoderma) and ear infections (otitis externa) in dogs, are becoming resistant to common antibiotics. Out of 74 samples collected from affected dogs, nearly 19% to 27% showed resistance to fluoroquinolone antibiotics, which are often used to treat these infections. Alarmingly, some bacteria were resistant to all five fluoroquinolones tested. This growing resistance could pose a risk not only to pets but also to public health, highlighting the importance of careful antibiotic use in veterinary medicine.
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Abstract
Recently, a total of 74 Staphylococcus pseudintermedius isolates were collected from clinical cases of canine pyoderma and otitis externa in Korea. In this study, we examined in vitro fluoroquinolone resistance among those isolates using a standard disk diffusion technique. The results demonstrated that approximately 18.9% to 27.0% of the isolates possessed bacterial resistance to both veterinary- and human-licensed fluoroquinolones except one isolate, including moxifloxacin (18.9% resistance), levofloxacin (20.3% resistance), ofloxacin (24.3% resistance), ciprofloxacin (25.7% resistance), and enrofloxacin (27.0% resistance). Most surprisingly, 14 out of 74 (18.9%) isolates were resistant to all the five fluoroquinolones evaluated. Moreover, a PCR detection of the methicillin resistance gene (mecA) among the 74 isolates revealed that 13 out of 25 (52.0%) mecA-positive isolates, but only 7 out of 49 (14.3%) mecA-negative isolates, were resistant to one or more fluoroquinones. Taken together, our results imply that bacterial resistance to both veterinary- and human-use fluoroquinolones becomes prevalent among the S. pseudintermedius isolates from canine pyoderma and otitis externa in Korea as well as that the high prevalence of the mecA-positive S. pseudintermedius isolates carrying multiple fluoroquinolone resistance could be a potential public health problem.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20467256/