High-rate pacing guided by short-term variability of repolarization prevents imminent ventricular arrhythmias automatically by an implantable cardioverter-defibrillator in the chronic atrioventricular block dog model.

Abstract

BACKGROUND: The anesthetized, complete chronic atrioventricular block (CAVB) dog model allows reproducible inducibility of torsades de pointes (TdP) arrhythmias due to ventricular remodeling and after a challenge with an Iblocker. High-rate pacing (HRP) prevents ventricular arrhythmias but has long-term detrimental effects on cardiac function when applied continuously. Temporal dispersion of repolarization, quantified as short-term variability (STV), increases before ventricular arrhythmias and has been proposed as a marker to guide HRP. OBJECTIVE: The purpose of this proof-of-principle study was to show that automatically determined STV can guide HRP to prevent imminent ventricular arrhythmias. METHODS: Eight CAVB dogs were implanted with an implantable cardioverter-defibrillator (ICD) with software to automatically determine STV (STV) in real time. During HRP, STV was measured offline from right ventricular (RV) electrograms (EGMs) and left ventricular (LV) monophasic action potential durations (MAPDs) (STV). The CAVB dogs were challenged twice with dofetilide (0.025 mg/kg intravenously over 5 minutes or until the first TdP). In experiment 1, the individual STVthreshold before the first arrhythmic event was determined and programmed into the ICD. In experiment 2, HRP with 100 bpm was initiated automatically once the STVthreshold was reached. RESULTS: In experiment 1, 8 of 8 dogs had repetitive TdP, and STVincreased from 0.96 &#xb1; 0.42 ms to 2.10 &#xb1; 1.26 ms (P <.05). In experiment 2, all dogs reached the STV threshold. HRP decreased STVfrom 2.02 &#xb1; 1.12 ms to 0.78 &#xb1; 0.28 ms, which was accompanied by prevention of TdP in 7 of 8 dogs. CONCLUSION: STV can guide HRP automatically by an ICD to prevent ventricular arrhythmias.