High Suitcordance for Panvascular Full-Watershed Organs: A New Interventional Perspective.

Abstract

Panvascular medicine underscores the integration of vascular networks across organs such as the heart, brain, kidneys, and limbs into a unified system. In this system, metabolic aberrations, endothelial dysfunction, and hemodynamic disturbances in one organ can drive synergistic pathologies elsewhere. However, current interventional device development has largely overlooked richly vascularized, high-perfusion organs like the liver and kidneys. Furthermore, the pervasive challenge of "low suitcordance"-a term we introduce to describe suboptimal device performance over its entire life cycle-confronting interventional devices for panvascular full-watershed organs remains unresolved. (Here, the term "full-watershed" metaphorically denotes organs that, like geographical watersheds, receive marked perfusion from the systemic circulation, emphasizing their collective role in panvascular health.) This article introduces "suitcordance" (short-term suitability and long-term concordance) as a novel framework for evaluating device performance that transcends traditional metrics like biocompatibility. We propose that interdisciplinary innovation, fusing materials science, biomechanics, mechanobiology, and artificial intelligence can address this gap. The Xinsorb bioresorbable scaffold illustrates a path toward "high suitcordance" devices, offering a paradigmatic reference for interventions in cerebral, peripheral, hepatic, and renal vasculatures. This approach provides a new paradigm for advancing interventional devices from isolated vascular repair to the synergistic management of multivascular bed lesions and the restoration of systemic functional equilibria.