Peer-reviewed veterinary case report
High-throughput sequencing in veterinary infection biology and diagnostics.
- Journal:
- Revue scientifique et technique (International Office of Epizootics)
- Year:
- 2013
- Authors:
- Belák, S et al.
Plain-English summary
Recent advancements in DNA sequencing technology have made it much easier and cheaper for veterinarians to identify germs like viruses and bacteria that can make pets sick. This new method, called high-throughput sequencing (HTS), allows labs to quickly analyze samples and find out what infections might be present. The World Organisation for Animal Health has shared insights on how these techniques can be used in veterinary medicine to improve diagnosis and treatment of infectious diseases. They also highlighted the importance of having the right computer tools to help make sense of the data. Overall, these developments are promising for better managing infections in pets.
Abstract
Sequencing methods have improved rapidly since the first versions of the Sanger techniques, facilitating the development of very powerful tools for detecting and identifying various pathogens, such as viruses, bacteria and other microbes. The ongoing development of high-throughput sequencing (HTS; also known as next-generation sequencing) technologies has resulted in a dramatic reduction in DNA sequencing costs, making the technology more accessible to the average laboratory. In this White Paper of the World Organisation for Animal Health (OIE) Collaborating Centre for the Biotechnology-based Diagnosis of Infectious Diseases in Veterinary Medicine (Uppsala, Sweden), several approaches and examples of HTS are summarised, and their diagnostic applicability is briefly discussed. Selected future aspects of HTS are outlined, including the need for bioinformatic resources, with a focus on improving the diagnosis and control of infectious diseases in veterinary medicine.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24761741/