Higher BMI increases risk of stoma-site incisional hernia and other complications following diverting loop ileostomy and reversal: a systematic review and meta-analysis.

Abstract

<h4>Background</h4>Diverting loop ileostomies (DLI) are commonly used to protect high-risk anastomoses. While a higher body mass index (BMI) is known to increase postoperative morbidity, its specific effect on DLI-related complications is less well understood.<h4>Methods</h4>This systematic review and meta-analysis followed PRISMA guidelines, and Cochrane Library, Embase, PubMed, and Google Scholar were searched for English publications without time restrictions. Statistical analysis was performed using Meta-Mar v3.5.1.<h4>Results</h4>Out of 586 studies yielded and 6 manually retrieved, 26 were included, totaling 5,141 patients (53.5% male). The mean ages were 35.0-65.3 years, and the mean BMI was 19.8-27.1 kg/m². Higher BMI increased stoma-site incisional hernia in 100% (n = 7) with a standardized mean difference of 0.88 (95% CI, 0.34-1.42). Two studies (40%) reported increased peristomal skin complications. One study each (100%) found increased risk for delayed reversal, stoma outlet obstruction, stoma-specific morbidity score, and longer operative time. Elevated BMI increased anastomotic leakage in 2 studies (50%), surgical site infection in 1 (33%), permanent stoma in 1 (20%), and overall complications in 2 (67%). However, no significant BMI differences were seen for high-output ileostomies, stoma retraction, parastomal hernia, complications after reversal, length of hospital stay, or mortality. BMI > 30 was associated with higher complication risks overall (OR [95% CI], 2.01 [1.11-3.64]), but BMI > 25 showed no significant difference except for stoma-site incisional hernia (OR [95% CI], 4.66 [3.54-6.14]) and parastomal hernia (OR [95% CI], 2.41 [1.70-3.40]).<h4>Conclusion</h4>Increased BMI is a risk factor for certain DLI-related complications, particularly stoma-site incisional hernia. If feasible, mesh placement at the ileostomy site should be strongly considered for patients with a BMI > 25 to reduce the risk of stoma-site incisional hernia. Weight loss prior to DLI and reversal should be encouraged.