Peer-reviewed veterinary case report
American Staffordshire terrier with severe ulcerative colitis and E
By Argenta, F F et al.·Published in Journal of comparative pathology·2018·Department of Veterinary Pathology, Brazil·View original on PubMed →
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Original publication title: Histiocytic Ulcerative Colitis in an American Staffordshire Terrier.
- Species:
- dog
Plain-English summary
A 9-year-old female American Staffordshire Terrier was brought to the vet with severe diarrhea, weakness, low body temperature, dehydration, and anemia. Unfortunately, she passed away six days later. A post-mortem examination revealed significant inflammation and ulceration in her large intestine, along with the presence of a specific type of E. coli bacteria. This case is notable as it is the first reported instance of histiocytic ulcerative colitis (a serious intestinal condition) in this breed, which is more commonly seen in boxers.
People also search for: dog diarrhea treatment · American Staffordshire Terrier intestinal disease · histiocytic ulcerative colitis in dogs
Abstract
A 9-year-old female American Staffordshire terrier was presented to a veterinary hospital with diarrhoea, severe prostration, hypothermia, dehydration and anaemia. The dog died 6 days after the first consultation. At necropsy examination the serosa of the large intestine showed a granular appearance and the mucosa was thickened, ulcerated and red, with prominent folding. Histological examination revealed marked inflammatory infiltration of macrophages into the mucosa and submucosa of the large intestine. These cells stained positively by the periodic acid-Schiff reaction. Immunohistochemistry showed marked presence of intracytoplasmic Escherichia coli in the macrophages. Bacteriological examination of intestinal sections yielded E. coli growth and the isolate displayed atypical characteristics when compared with strains associated with previously published cases of histiocytic ulcerative colitis (HUC). The molecular characterization showed that the isolate harboured none of the genes associated with enterotoxigenic E. coli strains and harboured only a limited number of genes associated with extra-intestinal pathotypes. Adherent and invasive E. coli are unlikely to have been involved in the pathogenesis of HUC in the present case. HUC is a rare disease with a predisposition for boxer dogs; however, sporadic occurrence in other breeds may occur. This is the first reported case of HUC in an American Staffordshire terrier.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30502794/