Peer-reviewed veterinary case report
Feline humeral condyle osteoarthritis changes in cartilage and bone
By Ryan, John M et al.·Published in BMC veterinary research·2013·Royal (Dick) School of Veterinary Studies and Roslin Institute, United Kingdom·View original on PubMed →
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Original publication title: Histological and molecular characterisation of feline humeral condylar osteoarthritis.
- Species:
- cat
Plain-English summary
A 10-year-old cat was diagnosed with osteoarthritis (OA) in the elbow joint, which can cause pain and difficulty moving. The study found that cats with OA had fewer healthy cartilage cells and changes in the bone structure around the joint. These findings suggest that OA affects the joint's cartilage and bone, particularly on the inner side of the elbow. While the study highlights the changes associated with OA, more research is needed to understand how factors like age and weight contribute to the disease.
People also search for: cat osteoarthritis symptoms · older cat joint pain · treatment for cat elbow arthritis
Abstract
BACKGROUND: Osteoarthritis (OA) is a clinically important and common disease of older cats. The pathological changes and molecular mechanisms which underpin the disease have yet to be described. In this study we evaluated selected histological and transcriptomic measures in the articular cartilage and subchondral bone (SCB) of the humeral condyle of cats with or without OA. RESULTS: The histomorphometric changes in humeral condyle were concentrated in the medial aspect of the condyle. Cats with OA had a reduction in articular chondrocyte density, an increase in the histopathological score of the articular cartilage and a decrease in the SCB porosity of the medial part of the humeral condyle. An increase in LUM gene expression was observed in OA cartilage from the medial part of the humeral condyle. CONCLUSIONS: Histopathological changes identified in OA of the feline humeral condyle appear to primarily affect the medial aspect of the joint. Histological changes suggest that SCB is involved in the OA process in cats. Differentiating which changes represent OA rather than the aging process, or the effects of obesity and or bodyweight requires further investigation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23731511/