Peer-reviewed veterinary case report
Adrenal gland changes in dogs with Cushing's treated with trilostane
By Reusch, C E et al.·Published in The Veterinary record·2007·Clinic for Small Animal Internal Medicine·View original on PubMed →
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Original publication title: Histological evaluation of the adrenal glands of seven dogs with hyperadrenocorticism treated with trilostane.
- Species:
- dog
Plain-English summary
A group of seven dogs with Cushing's disease (hyperadrenocorticism) were treated with a medication called trilostane. After treatment, the adrenal glands of these dogs showed various changes, including some with severe cell death and damage. Most of the dogs had issues with their adrenal glands, which could lead to further complications like low adrenal function (hypoadrenocorticism). The findings suggest that while trilostane can help manage Cushing's disease, it may also cause some serious side effects in the adrenal glands.
People also search for: dog Cushing's disease treatment · trilostane side effects in dogs · dog adrenal gland problems
Abstract
The lesions in the adrenal glands of seven dogs with hyperadrenocorticism that had been treated with trilostane were studied histologically. The glands of the six dogs with pituitary-dependent hyperadrenocorticism had moderate to severe cortical hyperplasia that was either diffuse or nodular. The lesions were more pronounced in the zona fasciculata than in the zona reticularis, and the zona glomerulosa was normal. In the dog with a functional adrenal tumour the non-tumour bearing adrenal gland showed mild nodular hyperplasia. Five of the seven dogs had variable degrees of adrenal necrosis, which was severe in two of them. The terminal deoxynucleotidyl transferase-mediated DUTP nick-end labelling (TUNEL) reaction specified areas of cell death as apoptosis in three of the dogs, and was positive in one of the dogs without visible areas of cell death. There were variable degrees of cortical haemorrhage in three of the dogs. In some of the dogs the lesions were severe enough to lead to hypoadrenocorticism.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17308018/