Peer-reviewed veterinary case report
Stomach tissue changes in dogs with kidney failure
By Peters, Rachel M et al.·Published in Journal of veterinary internal medicine·2005·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Histopathologic features of canine uremic gastropathy: a retrospective study.
- Species:
- dog
Plain-English summary
A group of 28 dogs with kidney failure showed signs of stomach problems, including vomiting and loss of appetite. Researchers found that most of these dogs had changes in their stomach tissue, which were linked to their kidney issues. While many had mild to moderate stomach changes, only one dog had a stomach ulcer. This suggests that while stomach problems are common in dogs with kidney failure, serious issues like ulcers are rare.
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Abstract
Uremic gastritis is a term commonly used to describe the gastrointestinal signs and histopathologic changes associated with renal failure in the dog. This retrospective study reviews the clinical, serum biochemical, and postmortem histopathologic data from 28 dogs with renal failure to determine the prevalence of gastric histopathology, characterize the gastric histopathology, and identify associations between gastric histopathology and serum concentrations of blood urea nitrogen (BUN), creatinine (Cr), calcium-phosphorus product (Ca x Phos), and hematocrit. Affected and control dogs with available renal and gastric tissue, serum biochemistry data, and urinalysis data were identified over a 10-year period (1992-2002) in the pathology department postmortem examination database at the Cornell University College of Veterinary Medicine. The serum biochemistry data and histopathologic findings were scored as normal, mild, moderate, and severe. All affected dogs had derangements of BUN, Cr, or Ca x Phos with gastric histopathology in 22 of 28 dogs (79%). Dogs with renal failure had a higher prevalence of gastric histopathologic changes compared with the control group. Associated histopathologic changes in the stomach were edema (P = .008), mineralization (P = .03), and vasculopathy (P = .03). Only 1 dog had evidence of gastric ulceration. Gastric necrosis was an uncommon finding (4/28, 14%). Gastric histopathology appears to be common in dogs with renal failure and is associated with increasing severity in the serum biochemistry data. Unlike humans with renal failure, in whom gastric ulceration predominates, gastric necrosis and ulceration appear to be uncommon in dogs with renal failure.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15954544/