Peer-reviewed veterinary case report
Eye tissue changes in Shih Tzu dogs with vitreoretinopathy
By Papaioannou, Nikolaos G & Dubielzig, Richard R·Published in Journal of comparative pathology·2013·Department of Pathology·View original on PubMed →
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Original publication title: Histopathological and immunohistochemical features of vitreoretinopathy in Shih Tzu dogs.
- Species:
- dog
Plain-English summary
A group of Shih Tzu dogs, averaging 10 years old, were found to have serious eye problems known as vitreoretinopathy, which included retinal detachment and tears. These conditions can lead to vision loss and were confirmed through microscopic examination of eye tissue. The study highlighted the presence of certain cells and proteins in the eye that are associated with these issues. Unfortunately, the findings suggest that these eye problems are common in older Shih Tzus, and treatment options may be limited depending on the severity of the condition.
People also search for: Shih Tzu eye problems · retinal detachment in dogs · treatment for dog cataracts
Abstract
Fifty cases of Shih Tzu ocular vitreoretinopathy were selected from the database of the Comparative Ocular Pathology Laboratory of Wisconsin. Cases with severe coexisting conditions (e.g. corneal disease, uveitis or endophthalmitis) were excluded. Microscopical changes were evaluated and immunohistochemistry was used to define spindle cells, gliosis and the presence of basement membranes in the vitreous. Expression of glial fibrillary acidic protein, vimentin and smooth muscle actin was also performed. The mean age of the 50 cases was 10.1 years (range 2.5-15 years). The most characteristic microscopical abnormalities (50/50 cases) were retinal detachment and extensive retinal tear. Additionally, extracellular, eosinophilic matrix material admixed with few spindle cells, and pre-iridal fibrovascular membrane, goniodysgenesis, secondary glaucoma, hypermature and subcapsular cataract were detected. The spindle cells within the collagen matrix were strongly labelled for expression of vimentin, with weaker expression of smooth muscle actin.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22819016/