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Peer-reviewed veterinary case report

Genital tumors and transmissible venereal tumor in dogs in Eastern

By Zahra Gabli & Zouhir Djerrou·Published in Revista Científica·2025·University 20 August 1955 – Skikda, Faculty of Sciences, Natural and Life Sciences Department. Algeria., VE·View original on DOAJ

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Original publication title: Histopathological characterization of genital tumors, with emphasis on Transmissible Venereal Tumor in the canine species in Eastern Algeria

Species:
dog

Plain-English summary

A group of dogs in Eastern Algeria was diagnosed with genital tumors, particularly a type of cancer called Transmissible Venereal Tumor (TVT), which often appears as masses on the external genital organs. This cancer mainly affects young, sexually active dogs, with males showing tumors on the penis and females on the vulva. Diagnosis involved examining the dog's medical history and the appearance of the tumors, confirmed through special staining techniques. Treatment typically included vincristine chemotherapy, sometimes alongside surgery, which helped many dogs recover from this condition.

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Abstract

This study aimed to provide data on genital tumors in canines at the Ibn Badis University Hospital Center in Constantine, focusing on tumor localization and histological types in Eastern Algeria. Transmissible venereal tumor, also known as Sticker sarcoma, is a significant cancer in dogs, prevalent across all breeds and primarily affecting urban stray populations. It typically manifests as masses on external genital organs but can also appear on other mucous membranes through direct contact. Transmissible venereal tumor predominantly affects dogs aged 2–5 years with high sexual activity; in males, it occurs in the penis and prepuce (6.66%) (8/120), while in females, it affects the posterior vaginal region and vulva (10%) (12/120). Diagnosis is based on clinical history, chronic discharge, typical lesion locations, and histopathological features confirmed by Hematoxylin & Eosin staining. The immunohistochemical analysis used desmin and myogenin to differentiate Transmissible venereal tumor cells and confirm diagnosis. Vincristine chemotherapy remains the primary treatment, often combined with surgery.

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Original publication on DOAJ: https://doi.org/10.52973/rcfcv-e35698