Peer-reviewed veterinary case report
New less invasive tests to diagnose histoplasmosis in cats
By Palha de Brito Jardim, Mariana et al.·Published in Journal of feline medicine and surgery·2024·Department of Veterinary Medicine and Surgery, Brazil·View original on PubMed →
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Original publication title: Histoplasmosis in domestic cats: new minimally invasive diagnostic techniques.
- Species:
- cat
Plain-English summary
A group of eight domestic cats diagnosed with histoplasmosis, a fungal infection that can affect their lungs and other organs, underwent new tests to confirm the disease. The tests included a blood test for antibodies and a urine test for antigens, both of which showed high accuracy in detecting the infection. The combination of these tests was able to identify the disease in most of the cats, helping veterinarians diagnose and treat histoplasmosis more effectively. This approach offers a less invasive way to confirm the presence of this serious condition in cats.
People also search for: cat histoplasmosis symptoms · cat fungal infection treatment · how to test for histoplasmosis in cats
Abstract
OBJECTIVES: The aim of the present study was to evaluate minimally invasive diagnostic techniques, such as the semi-quantitative indirect IgG antibody enzyme immunoassay (EIA) using blood serum and the urinary lateral flow assay (LFA), for the detection ofin cats with histoplasmosis. METHODS: Eight client-owned domestic cats diagnosed with histoplasmosis were selected based on cytological, histopathological, mycological, molecular or antigenic techniques. The blood serum of these animals was tested in a semi-quantitative indirect IgG antibody EIA for the detection of. Urine samples were tested forantigen using LFA. RESULTS: Five cats were seropositive on IgG EIA (5/8, with diagnostic sensitivity equal to 62.5%; 95% confidence interval [CI] 24.5-91.5) and five cats were positive onantigen LFA (5/7, with diagnostic sensitivity equal to 71.4%; 95% CI 29.0-96.3). The combined diagnostic sensitivity when interpreted in parallel was 87.5% (7/8, 95% CI 47.3-99.7). The specificity for the anti-IgG EIA was 100% (95% CI 71.5-100) and for theantigen LFA it was also 100% (95% CI 71.5-100). CONCLUSIONS AND RELEVANCE: The semi-quantitative indirect IgG antibody EIA for the detection ofin blood serum and the urinary LFA for the detection of the same agent emerge as new minimally invasive diagnostic techniques that can assist in the approach to disseminated and pulmonary feline histoplasmosis, especially when both techniques are considered together.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38857445/