Peer-reviewed veterinary case report
Noninvasive ultrasound treatment effects on dog prostate over 28 days
By Hall, Timothy L et al.·Published in Urology·2009·Department of Urology, United States·View original on PubMed →
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Original publication title: Histotripsy of the prostate: dose effects in a chronic canine model.
- Species:
- dog
Plain-English summary
A group of 20 dogs with prostate issues were treated using a new noninvasive ultrasound therapy called histotripsy to help with benign prostatic hyperplasia, which can cause urination problems. The treatment involved applying different doses of histotripsy to see how well it worked. Higher doses were more effective at breaking down prostate tissue, allowing it to be expelled during urination, while lower doses caused minimal damage. This promising technique could provide a new way to relieve symptoms without surgery, but further development is needed before it becomes widely available.
People also search for: dog prostate problems treatment · benign prostatic hyperplasia in dogs · noninvasive prostate therapy for dogs
Abstract
OBJECTIVES: To develop the technique of histotripsy ultrasound therapy as a noninvasive treatment for benign prostatic hyperplasia and to examine the histotripsy dose-tissue response effect over time to provide an insight for treatment optimization. We have previously demonstrated the feasibility of prostate histotripsy fractionation in a canine model. METHODS: Various doses of histotripsy were applied transabdominally to the prostates of 20 canine subjects. Treated prostates were then harvested at interval time points from 0 to 28 days and assessed for histologic treatment response. RESULTS: The lowest dose applied was found to produce only scattered cellular disruption and necrosis, whereas higher doses produced more significant regions of tissue effect that resulted in sufficient fractionation of tissue so the material could be voided with urination. Urethral tissue was more resistant to the lower histotripsy doses than was parenchymal tissue. Treatment of the urethra at the lowest doses appeared to heal, with minimal long-term sequelae. CONCLUSIONS: Histotripsy was effective at fractionating parenchymal and urethral tissue in the prostate, in the presence of a sufficient dose. Further development of this technique could lead to a noninvasive method for debulking the prostate to relieve symptoms associated with benign prostatic hyperplasia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19628261/