Peer-reviewed veterinary case report
HLDF-6 peptide relieves symptoms of abstinence syndrome during experimental opium abuse.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2004
- Authors:
- Litvinova, S V et al.
- Affiliation:
- Department of Higher Nervous Activity
- Species:
- rodent
Abstract
Experiments were performed on rats with opium abuse induced by chronic administration of morphine in increasing doses. We studied the effect of HLDF-6 peptide on symptoms of naloxone abstinence. Repeated administration of HLDF-6 peptide in a dose of 0.2 mg/kg 24 and 0.5 h before naloxone relieved the major symptoms of the abstinence syndrome. A possible neurochemical mechanism underlying the effect of HLDF-6 peptide is inhibition of enkephalinase A in structures of the endogenous antinociceptive system.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15455114/