Peer-reviewed veterinary case report
Dog with hookworm diarrhea not cured by usual medicine has
By Evason, Michelle et al.·Published in Journal of the American Animal Hospital Association·2024·From Antech Diagnostics, United States·View original on PubMed →
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Original publication title: Hookworm Anthelmintic Resistance: Novel Fecal Polymerase Chain Reaction Ancylostoma caninum Benzimidazole Resistance Marker Detection in a Dog.
- Species:
- dog
Plain-English summary
A 4-year-old male greyhound had chronic diarrhea for over three weeks and was found to have a hookworm infection (Ancylostoma caninum). After standard treatments failed to clear the infection, a special test detected the hookworm and a genetic marker indicating resistance to common dewormers. The vet then used a different medication called emodepside, which is not typically approved for dogs in the U.S. This treatment worked, and the dog's diarrhea resolved, but five months later, the hookworm returned along with another infection. The vet continued the emodepside treatment, and follow-up tests showed the hookworm was no longer detected.
People also search for: dog diarrhea treatment · greyhound hookworm infection · emodepside for dogs · persistent hookworm in dogs · dog deworming resistance
Abstract
A 4 yr old castrated male greyhound presented with a history of chronic (>3 wk) intermittent diarrhea. Initial fecal analysis identified infection with Ancylostoma caninum. Despite treatment with routine anthelmintics, the dog remained persistently A caninum positive for several months. A novel fecal gastrointestinal real-time polymerase chain reaction (qPCR) parasite panel detected A caninum and the genetic benzimidazole (BZ) F167Y resistance marker in multiple samplings over 48 hr. This finding, together with the dog's clinical signs (diarrhea) and lack of response to routine anthelmintics, prompted treatment with cyclooctadepsipeptide emodepside, a drug currently not registered for dogs in the United States. The dog's clinical signs resolved and post-treatment fecal qPCR testing was negative. However, 5 mo later, retesting with fecal qPCR detected A caninum and concurrent BZ resistance marker, as well as Giardia. A presumptive diagnosis of re-infection was made and the emodepside treatment was continued. The dog again reverted to undetected (A caninum and the 167 resistance marker) on reassessment fecal qPCR. This case report describes the use of a novel fecal qPCR panel for gastrointestinal parasites, persistent hookworm and BZ F167Y resistance marker detection in a dog, and highlights the importance of a stepwise approach to clinical management, treatment, and retesting.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38394692/