Peer-reviewed veterinary case report
Hormonal Stimulation in a Gonadal Dysgenesis Mare.
- Journal:
- Journal of equine veterinary science
- Year:
- 2020
- Authors:
- Larentis, Gustavo Rupp et al.
- Affiliation:
- REPROLAB - Faculdade de Veteriná · Brazil
- Species:
- horse
Plain-English summary
This case involved a mare with a condition called gonadal dysgenesis, which means her ovaries didn't develop normally. The mare was examined and found to have a smaller than usual uterus and small, smooth ovaries. Hormonal tests showed that her hormone levels were low, but tests also indicated that her uterus had the ability to respond to hormones. After receiving hormone treatments, there were some positive changes in her uterus, but her ovaries did not show any improvement. Ultimately, the owner chose not to pursue further treatment or follow-up.
Abstract
The present case report aimed to determine the responsiveness of the endometrium and the ovaries of an X0 mare after hormonal treatment. On transrectal palpation, the uterus was flaccid and smaller than normal, and the ovaries were small and smooth. The endometrium had normal histological architecture, with an atrophic glandular epithelium. A karyotype evaluation was performed, and 70 cells presented 63 chromosomes, lacking one sex chromosome. Circulating hormonal levels of total estrogens were 43.93 pg/mL; progesterone 0.01 ng/mL; testosterone 48 pg/mL; FSH 30.3 ng/mL; and LH 1.71 ng/mL. Immunohistochemistry tests showed the presence of estrogens and progesterone receptors in the endometrial samples of the X0 mare. 17β estradiol was administrated on three consecutive days and long-action progesterone on the fourth day. After hormonal stimulation, the mare showed changes in endometrial ultrasonography and histology. After treatment with estradiol, uterine edema was noted, and after progesterone, a reduction in edema was observed. At the request of the owner, no further treatment or follow-up occurred. This report showed that the endometrium is functional, but the ovaries did not change macroscopically under hormonal therapy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32797782/