Peer-reviewed veterinary case report
-host interplay of disseminated mucormycosis in immunocompetent mice.
- Journal:
- Future microbiology
- Year:
- 2020
- Authors:
- Dos Santos, Amanda R et al.
- Affiliation:
- Universidade Estadual Paulista (Unesp) · Brazil
- Species:
- rodent
Abstract
To investigate the immune response of disseminatedinfection in immunocompetent mice.C57Bl/6, BALB/c and Swiss wild-type mice were intravenously infected with; the parameters of infection and immune response were determined. Transcriptional signature of Th17 immune response and infection inmice were also evaluated.All mouse strains showed an initial spread ofin the target tissues; however, after 30 days, C57Bl/6 and BALB/c mice showed an effective fungal clearance associated with specific production of IL-17 and IL-2. We also observed that 60% ofmice succumbed to infection within 16 days.This study has established an immunocompetent model for disseminated mucormycosis and highlighted the role of IL-17 signaling in immunity against.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32686962/