Peer-reviewed veterinary case report
Human brain MRI showing tracer spread after spinal injection over 72
By Riseth JN et al.·2026·Scientific Computing and Numerical Analysis (SCAN)·View original on Europe PMC →
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Original publication title: Human brain MRI data of intrathecally injected tracer evolution over 72 hours for data-integrated simulations.
Plain-English summary
This study focuses on a dataset called the Gonzo dataset, which includes brain MRI scans from a healthy male volunteer who received an injection of a contrast agent called gadobutrol into the fluid around his spinal cord. The researchers tracked how this contrast agent moved through the brain and surrounding areas over 72 hours. They provided various types of data, including images and maps that show how the contrast agent spread and concentrated in different brain regions. This information is meant to help scientists better understand how substances move in the brain and improve methods for analyzing brain images. Overall, the study aims to inspire further research into brain fluid transport processes.
Abstract
We present the Gonzo dataset: Brain MRI with processed and derivative data from one healthy male human volunteer ("Gonzo") before and during the 72 hours after intrathecal injection of the contrast agent gadobutrol into the cerebrospinal fluid (CSF) of the spinal canal. The MRI data records include images highlighting the temporal and spatial evolution of the contrast agent in CSF, brain, and adjacent structures. In addition to raw MRI, we provide derivatives that enable numerical simulations of the transport process under study. Derivatives include T<sub>1</sub> maps, tracer concentration maps, diffusion tensor maps, and unstructured triangulated volume meshes of the brain geometry. We also provide brain region markers obtained by image segmentation. A regional statistical analysis of the concentration data complements the image data. The presented data can be used to study the transport behavior and the underlying processes of a tracer in the brain. It is intended to contribute to and inspire new studies on the understanding of tracer transport, method development for image analysis, and simulation of brain fluid transport processes.
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Search related cases →Original publication on Europe PMC: https://europepmc.org/article/MED/41559112