Peer-reviewed veterinary case report
Human cryptosporidiosis in immunocompetent and immunodeficient persons. Studies of an outbreak and experimental transmission.
- Journal:
- The New England journal of medicine
- Year:
- 1983
- Authors:
- Current, W L et al.
- Species:
- dog
Plain-English summary
This study looked at how a germ called cryptosporidium, which can cause illness, affected people who have normal immune systems and those who have weakened immune systems. Twelve healthy people got sick after being in contact with the poop of infected calves, experiencing diarrhea and stomach cramps for up to ten days. The researchers found the germ in the feces of the infected people and calves, but not in other animals. While healthy individuals had a mild illness that went away on its own, those with weakened immune systems suffered from severe and lasting diarrhea. The findings suggest that calves with diarrhea can spread this germ to humans, so it's important for people with weakened immune systems to stay away from them.
Abstract
Infection with cryptosporidium occurred in 12 immunocompetent persons who had direct contact with the feces of infected calves during three unrelated outbreaks of calf cryptosporidiosis. Nine of the twelve subjects had diarrhea and abdominal cramps that lasted 1 to 10 days. Infections were diagnosed and monitored by detection of oocysts in feces, with a modified Sheather's flotation technique and phase-contrast microscopy. Oocysts of cryptosporidium were isolated from calves but not from other animals with which these subjects had been in contact. Oocysts of cryptosporidium were also detected during repeated examinations of feces from two immunodeficient patients with persistent cryptosporidiosis. An apparently identical infection was transmitted to calves and mice, using oocysts from infected calves and human beings. Oocysts from an immunodeficient person also produced infections in kittens, puppies, and goats. This study shows that cryptosporidium may produce a moderate self-limited illness in immunocompetent persons, which contrasts sharply with the prolonged severe diarrhea in immunocompromised patients who contract cryptosporidiosis. Calves with diarrhea should be considered a potential source of human infection, and immunocompromised persons should avoid contact with such animals.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/6843609/