Peer-reviewed veterinary case report
Human Xenograft Model.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2024
- Authors:
- Liu, Shuang
- Affiliation:
- Department of Pharmacology · Japan
- Species:
- rodent
Abstract
Human-SCID grafting is a commonly used technique for the long-term investigation of rheumatoid arthritis (RA) explants. To establish a chimeric immunological system in NOD/SCID mice, RA patient-derived pannus tissue from the synovial membrane, articular cartilage, and bone can be transplanted subcutaneously. Same patient-derived peripheral mononuclear cell chimerism can be successfully achieved by intraperitoneal engraftment. This xenograft model is able to be used for the initial screening of human target-specified biologics.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38270861/