Peer-reviewed veterinary case report
Humanin ameliorates diazepam-induced memory deficit in mice.
- Journal:
- Neuropeptides
- Year:
- 2017
- Authors:
- Murakami, Minetaka et al.
- Affiliation:
- Department of Information and Communication Sciences · Japan
- Species:
- rodent
Abstract
Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in rodents. To understand the effects of HN on brain function, we tested the effect of S14G-HN on diazepam (DZP)-induced memory impairment and anxiety in mice using the object recognition test and zero-maze test, respectively. Intraperitoneal injection of S14G-HN reversed the DZP-induced memory deficit, whereas no significant change was observed in behavioral markers of anxiety. S14G-HN had no effect on locomotor activity in either test, indicating that S14G-HN did not affect physical functioning or motivation. These results suggest that HN preferentially influences cognitive function but not emotional function in the central nervous system.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27814910/