Peer-reviewed veterinary case report
Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge.
- Journal:
- Clinical and vaccine immunology : CVI
- Year:
- 2016
- Authors:
- Van Slyke, Greta et al.
- Affiliation:
- New York State Department of Health · United States
- Species:
- rodent
Abstract
PB10 is a murine monoclonal antibody against an immunodominant epitope on ricin toxin's enzymatic subunit. Here, we characterize a fully humanized version of PB10 IgG1 (hPB10) and demonstrate that it has potent in vitro and in vivo toxin-neutralizing activities. We also report the minimum serum concentrations of hPB10 required to protect mice against 10 times the 50% lethal dose of ricin when delivered by injection and inhalation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27466351/