Peer-reviewed veterinary case report
Hyaluronic acid levels drop in dog joints with worse osteoarthritis
By Plickert, H D et al.·Published in Research in veterinary science·2013·Small Animal Clinic, Germany·View original on PubMed →
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Original publication title: Hyaluronic acid concentrations in synovial fluid of dogs with different stages of osteoarthritis.
- Species:
- dog
Plain-English summary
A study looked at the levels of hyaluronic acid in the joint fluid of dogs with different stages of osteoarthritis (OA). The researchers found that as the severity of OA increased, the amount of hyaluronic acid decreased. This means that while lower levels of hyaluronic acid might suggest more advanced OA, they cannot definitively determine how severe the condition is. The findings suggest that while hyaluronic acid levels can indicate some trends in joint health, they shouldn't be used alone to stage the disease.
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Abstract
To compare hyaluronic acid (HA) concentrations measured in synovial fluid (SF) of joints with different stages of canine secondary osteoarthritis (OA), clinical-orthopedic, radiographic, macroscopic intra-operative and SF findings of 49 joints were assessed. The sum of single findings was correlated to HA concentrations measured by a commercially available ELISA. Joints were categorized into three OA-groups: non-osteoarthritic, mildly osteoarthritic, and severely osteoarthritic. A significant negative correlation was found between severity of OA and HA concentrations (r=-0.696; P<0.001). Median values of HA concentrations decreased with increasing severity of the disease. Statistically significant differences in HA concentrations were observed between the OA-groups (P<0.001). Due to overlapping values between groups, it was concluded that synovial HA concentrations may only indicate a trend of osteoarthritic disease activity, but is not suitable for staging the disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23261156/