Peer-reviewed veterinary case report
Hydrocortisone Attenuates the Development of Malformations of the Polymicrogyria Spectrum.
- Journal:
- International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
- Year:
- 2025
- Authors:
- Savoldi, Laura Maria Borges et al.
- Affiliation:
- Department of Pathology · Brazil
- Species:
- rodent
Abstract
Most of the malformations of the polymicrogyria spectrum are caused by destructive lesions of the neocortex during the third trimester of pregnancy, triggered by hypoxic-ischemic, hemorrhagic or infectious events, with neuroinflammation as a common pathophysiological mechanism. Our study investigated hydrocortisone treatment in attenuating inflammation, malformations development and seizures predisposition in mice subjected to neonatal transcranial freeze lesion. Our results show attenuation of malformation and predisposition to febrile seizures, with concomitant reduction of macrophages/microglia after neonatal freeze lesion, polarizing them towards an anti-inflammatory profile. Thus, we have identified a promising treatment to minimize the development of cortical developmental malformations.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39873286/