Peer-reviewed veterinary case report
Hydroxyethyl starch vs saline for shock in greyhounds
By McBride, Duana et al.·Published in Veterinary anaesthesia and analgesia·2017·College of Veterinary Medicine, Australia·View original on PubMed →
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Original publication title: Hydroxyethyl starch 130/0.4 compared with 0.9% NaCl administered to greyhounds with haemorrhagic shock.
- Species:
- dog
Plain-English summary
A group of healthy greyhounds was put under anesthesia and had blood removed to simulate a state of shock. They were then given either a hydroxyethyl starch solution or a saline solution to see which would help their blood pressure and overall condition better. The results showed that while both treatments had similar effects on oxygen use, the dogs receiving hydroxyethyl starch had better blood pressure after treatment. However, the saline group showed signs of acidosis, likely due to the larger volume of fluid given.
People also search for: greyhound shock treatment · hydroxyethyl starch for dogs · saline solution effects in dogs
Abstract
OBJECTIVE: To determine the cardiovascular and acid-base effects of 6% hydroxyethyl starch (HES) 130/0.4 and 0.9% sodium chloride (NaCl) administered to anaesthetized greyhounds with haemorrhagic shock. STUDY DESIGN: Prospective, experimental, complete randomized block design. ANIMALS: Twelve healthy adult greyhounds. METHODS: After 60 minutes of isoflurane anaesthesia, 48 mL kgof blood was removed to induce hypotension. Dogs were randomized to receive either 20 mL kgof HES 130/0.4 or 80 mL kgof 0.9% NaCl over 20 minutes. Haemoglobin, arterial and central venous blood gas and electrolytes, lactate, mean arterial pressure (MAP) and cardiac index were measured at: T0, 60 minutes after induction of anaesthesia, immediately prior to blood removal; T1, immediately after blood removal; T2, immediately after fluid administration; and T3, 40 minutes after fluid administration. Oxygen extraction ratio (OER) was calculated at each sample time. RESULTS: OER increased at T1 and decreased at T2 and T3, with no difference between the two groups. Dogs administered HES 130/0.4 had higher lactate at T2 [mean (95% confidence interval) 1.3 (0.8-1.9) mmol L] than dogs administered 0.9% NaCl [0.8 (0.5-1.1) mmol L]; p = 0.045. Dogs administered HES 130/0.4 had a higher MAP at T3 [88 (74-102) mmHg] than dogs administered 0.9% NaCl [69 (60-79) mmHg]; p = 0.019. Dogs administered 0.9% NaCl were more acidaemic at T2 and T3, including higher hydrogen ion, lower bicarbonate, lower base excess and higher chloride concentrations. CONCLUSION: and clinical relevance The effect of 20 mL kgof HES 130/0.4 on shock, as measured by OER, was no different than that of 80 mL kgof 0.9% NaCl in dogs under general anaesthesia. Acidaemia in the NaCl group is likely attributable to hyperchloraemic metabolic acidosis from the larger volume administered.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28501489/