Peer-reviewed veterinary case report
Hyperadrenocorticism signs from adrenal tumors in two dogs
By Syme, H M et al.·Published in Journal of the American Veterinary Medical Association·2001·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Hyperadrenocorticism associated with excessive sex hormone production by an adrenocortical tumor in two dogs.
- Species:
- dog
Plain-English summary
An 11-year-old spayed female Labrador and a 9-year-old castrated male miniature Poodle were showing signs of Cushing's disease, like increased thirst and urination. Tests didn't show high cortisol levels, but imaging revealed adrenal tumors in both dogs that were producing excess sex hormones. The male Poodle underwent surgery to remove the tumor, and his symptoms improved afterward. Unfortunately, the female Labrador did not respond to medication and passed away two months later, with both dogs confirmed to have adrenal tumors.
People also search for: dog Cushing's disease symptoms · Labrador adrenal tumor treatment · miniature Poodle surgery recovery
Abstract
An 11-year-old spayed female Labrador Retriever and a 9-year-old castrated male miniature Poodle were evaluated because of clinical signs of hyperadrenocorticism. Cortisol testing did not support a diagnosis of hypercortisolemia in either dog; however, imaging studies revealed unilateral adrenal tumors in both dogs. Serum concentrations of 17-hydroxyprogesterone, progesterone, and estradiol were high in both dogs, and androstenedione concentrations were also high in 1 dog. It is suspected that sex hormone secretion by the adrenal tumors in these dogs resulted in clinical signs of hyperadrenocorticism. Clinical signs and hormonal abnormalities resolved in the male dog after surgical resection of the tumor. There was no improvement in clinical signs after treatment with mitotane in the female dog, which died 2 months after diagnosis. Histologic evaluation confirmed the presence of adrenocortical carcinoma in both dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11767922/