Peer-reviewed veterinary case report
Dog with Cushing's disease caused by pituitary tumor
By Ishino, Hirokazu et al.·Published in Veterinary pathology·2019·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Hyperadrenocorticism Caused by a Pituitary Ganglioglioma in a Dog.
- Species:
- dog
Plain-English summary
An 11-year-old male Chihuahua was brought to the vet with excessive thirst, frequent urination, a swollen belly, and hair loss. After tests, the vet diagnosed him with hyperadrenocorticism (Cushing's disease) caused by a tumor in the pituitary gland. The dog underwent surgery to remove the tumor, and afterward, his hormone levels returned to normal, resolving his symptoms. This case is unique as it links a specific type of tumor, called a ganglioglioma, to hyperadrenocorticism in dogs.
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Abstract
An 11-year-old castrated male Chihuahua dog was presented with complaints of polyuria, polydipsia, abdominal enlargement, and alopecia. Hyperadrenocorticism was diagnosed on the basis of clinical signs, blood tests, adrenocorticotropin-stimulation test results, and an elevated serum adrenocorticotropin concentration. Contrast-enhanced magnetic resonance imaging showed that the pituitary gland was enlarged, compatible with a pituitary macroadenoma. Pituitary-dependent hyperadrenocorticism was suspected, and transsphenoidal hypophysectomy was thus performed for complete resection of the tumor. After surgery, the serum adrenocorticotropin concentration normalized and the hyperadrenocorticism resolved. Histological and immunocytochemical analyses revealed a benign tumor composed of mature neuronal cells and glial cells, suggestive of a ganglioglioma with immunolabeling for adrenocorticotropin. Careful analysis of the resected tumor revealed no pituitary adenoma tissue. The clinical and histopathologic findings indicated that the ganglioglioma was directly responsible for the hyperadrenocorticism. This is the first case of hyperadrenocorticism caused by a ganglioglioma in a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30774022/