Peer-reviewed veterinary case report
Managing high ammonia brain symptoms in dogs
By Ahn, Jin-Ok et al.·Published in Journal of veterinary science·2016·Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: Hyperammonemic hepatic encephalopathy management through L-ornithin-L-aspartate administration in dogs.
- Species:
- dog
Plain-English summary
Seventeen dogs with high ammonia levels were treated with a medication called L-ornithin-L-aspartate (LOLA) to help improve their condition. After receiving LOLA, 15 of the dogs showed a significant drop in ammonia levels and improved clinical signs, meaning they felt better. However, two dogs did not show any improvement despite the lower ammonia levels. In a smaller group of dogs treated with lactulose, a more traditional therapy, there were also improvements, but they were not as significant. Overall, LOLA appears to be an effective treatment for high ammonia levels in dogs.
People also search for: dog high ammonia levels treatment · L-ornithin-L-aspartate for dogs · lactulose for dog liver disease
Abstract
Seventeen dogs were treated with L-ornithin-L-aspartate (LOLA; experimental group). Three dogs were treated with lactulose recognized therapy (control group). Following LOLA administration, 15 dogs experienced a significant decrease in ammonia level (p ＜ 0.05) and showed clinical signs of improvement. However, there were no clinical signs of improvement in two dogs, even though the ammonia level decreased. Conversely, the clinical signs of the control group also improved and the ammonia level decreased, although these changes were not significant (p ＞ 0.05). These results suggest that LOLA is an effective drug to treat hyperammonemia in veterinary medicine.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26726023/