Peer-reviewed veterinary case report
Blood clotting risk in dogs with chronic gut disease and normal
By Dixon, Amy et al.·Published in Journal of veterinary internal medicine·2021·Bristol Veterinary School, United Kingdom·View original on PubMed →
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Original publication title: Hypercoagulability in dogs with chronic enteropathy and association with serum albumin concentration.
- Species:
- dog
Plain-English summary
A group of dogs with chronic gastrointestinal issues, suspected to be caused by inflammatory bowel disease, were tested for a condition called hypercoagulability, which means their blood could clot too easily. Out of 38 dogs, 17 were found to be hypercoagulable, even though their serum albumin levels were normal. This suggests that dogs with chronic enteropathy (CE) can still have this risk regardless of their albumin levels. Understanding this can help veterinarians monitor and manage potential blood clotting issues in these dogs.
People also search for: dog chronic diarrhea treatment · dog inflammatory bowel disease symptoms · why is my dog at risk for blood clots
Abstract
BACKGROUND: Dogs with protein-losing enteropathy (PLE) are at risk of developing a hypercoagulable state, but the prevalence of hypercoagulability in dogs with chronic enteropathies (CE) and normal serum albumin concentration is unknown. HYPOTHESIS: Dogs with CE are predisposed to a hypercoagulable state as assessed by thromboelastography (TEG) independent of serum albumin concentration. METHODS: Dogs with chronic gastrointestinal signs from suspected inflammatory CE between 2017 and 2019 were included. Thirty-eight were evaluated; every dog had a CBC, serum biochemistry panel, and abdominal imaging performed. The Canine Inflammatory Bowel Disease Activity Index (CIBDAI) was calculated. Thromboelastography was performed at presentation, and reaction time (R), kinetic time (K), α-angle, maximal amplitude (MA), and global clot strength (G) were recorded. Dogs were considered hypercoagulable if the G value was ≥25% above the reference interval. RESULTS: Seventeen of 38 (44.7%; 95% confidence interval [CI], 28.6-61.7%) dogs with CE were hypercoagulable. The G value did not differ between the 19 dogs with normal (≥28 g/L) serum albumin concentrations (9.05 kdyn/cm; 95% CI, 7.26-10.84; SD 3.71) and 19 dogs with hypoalbuminemia (11.3 kdyn/cm; 95% CI, 9.04-13.6, SD; 4.7; P = .11). The G value was negatively correlated with hematocrit, serum albumin concentration, and duration of signs and positively correlated with age. CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with CE and normal serum albumin concentration can be hypercoagulable as measured by TEG.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33527508/