Peer-reviewed veterinary case report
High ferritin levels linked to malignant histiocytosis in a dog
By Newlands, C E et al.·Published in Journal of the American Veterinary Medical Association·1994·Department of Veterinary Pathology, Canada·View original on PubMed →
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Original publication title: Hyperferritinemia associated with malignant histiocytosis in a dog.
- Species:
- dog
Plain-English summary
A 3.5-year-old male Golden Retriever was brought in because he was very tired, had swollen lymph nodes, and an enlarged liver and spleen. After tests, the dog was diagnosed with malignant histiocytosis, a type of cancer that affects immune cells. Blood tests showed high levels of ferritin, which is a protein that stores iron, indicating significant iron buildup in the body. Monitoring these ferritin levels can help vets track how well the dog is responding to treatment.
People also search for: Golden Retriever lethargy · dog swollen lymph nodes cancer · malignant histiocytosis treatment in dogs
Abstract
A 3.5-year-old male Golden Retriever with lethargy, generalized lymphadenopathy, and hepatosplenomegaly was determined to have malignant histiocytosis, based on the morphologic appearance of neoplastic cells by light and electron microscopic examination, evidence of erythrophagocytosis, the presence of diffuse nonspecific esterase activity, and immunohistochemical demonstration of vimentin intermediate filaments. Because of the appearance of abundant iron stores in the bone marrow, serum was obtained for determination of iron, total iron binding capacity, and ferritin values. Serum ferritin concentrations were markedly increased. Measurement of serum ferritin concentrations may be useful in supporting a diagnosis of malignant histiocytosis, and the monitoring of serum ferritin concentrations may be useful for assessing treatment and regression of the disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/7829379/