Peer-reviewed veterinary case report
Hyperfibrinolysis in cats and its impact on survival
By Priego-Corredor, Anabel et al.·Published in Journal of veterinary internal medicine·2025·Veterinary Teaching Hospital of the Catholic University of Valencia (VTHCUV), Spain·View original on PubMed →
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Original publication title: Hyperfibrinolysis in Cats: A Retrospective Case-Control Study of 154 Cats.
- Species:
- cat
Plain-English summary
A group of 154 cats underwent a special blood test to check for a condition called hyperfibrinolysis (HFL), which affects how blood clots. The study found that cats with liver disease or fluid buildup in their bodies were more likely to have HFL, while those with heart disease were less likely to have it. Surprisingly, having HFL did not seem to impact the cats' chances of survival. This suggests that while certain health issues can increase the risk of HFL, it may not be as serious as previously thought.
People also search for: cat blood clotting problems · liver disease in cats · hyperfibrinolysis in cats · cat fluid buildup treatment
Abstract
BACKGROUND: Hyperfibrinolysis (HFL) has not been well described in cats. HYPOTHESIS/OBJECTIVES: Identify risk factors associated with HFL in cats and evaluate its association with survival. Our hypotheses were that cats share similar conditions as dogs and humans with HFL and that it is associated with a worse prognosis. ANIMALS: A total of 154 client-owned cats had thromboelastography (TEG) performed because of a variety of clinical conditions. METHODS: Retrospective case-control study. Cases were defined as cats with HFL (clot lysis at 30 min [LY30] ≥ 5% or clot lysis at 60 min [LY60] ≥ 10% or both) and controls were cats that had TEG performed but without HFL. Signalment, conditions that may alter fibrinolysis, TEG variables, indications to perform TEG, and outcome were recorded. RESULTS: Fifty-two cats (33.8%) with HFL and 102 controls (66.2%) were included. Demographic variables were similar between groups. Both liver disease (odds ratio [OR], 5.0; 95% confidence interval [CI], 2.4-10.6; p < 0.001) and the presence of cavitary effusion (OR, 5.9; 95% CI, 2.8-12.4; p < 0.001) were important risk factors for HFL. Cats with heart disease were less likely to have HFL (OR, 0.2; 95% CI, 0.1-0.5; p < 0.001). The presence of HFL was not associated with worse outcome (p = 0.84). Cats with HFL more often were hypocoagulable, whereas cats without HFL more often were hypercoagulable (p < 0.001). CONCLUSIONS AND CLINICAL IMPORTANCE: Liver disease and cavitary effusion are risk factors for HFL in cats. The presence of HFL did not affect survival.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40958760/