Peer-reviewed veterinary case report
High blood sugar lowers amylase and raises pancreas neutrophils
By Zini, Eric et al.·Published in Research in veterinary science·2010·Clinic for Small Animal Internal Medicine·View original on PubMed →
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Original publication title: Hyperglycaemia but not hyperlipidaemia decreases serum amylase and increases neutrophils in the exocrine pancreas of cats.
- Species:
- cat
Plain-English summary
A group of cats with diabetes were studied to see how high blood sugar (hyperglycaemia) affected their pancreas. Researchers found that four out of five hyperglycaemic cats had low levels of amylase, an enzyme important for digestion, while the number of certain immune cells (neutrophils) in their pancreas increased. However, the pancreas itself looked normal under a microscope, suggesting that high blood sugar might not be a major cause of pancreatitis in these cats. After starting insulin therapy to control their blood sugar, the amylase levels returned to normal within a week.
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Abstract
The goal of the study was to determine whether hyperglycaemia or hyperlipidaemia causes pancreatitis in cats and to assess the effect of excess serum glucose and lipids on amylase and lipase activity. Ten-day hyperglycaemic and hyperlipidaemic clamps were carried out in five and six healthy cats, respectively. Ten healthy cats received saline and served as controls. The activity of amylase was below the normal range in 4 of 5 hyperglycaemic cats by day 10. The activity of lipase did not vary in any of the cats. Samples of exocrine pancreas were normal on histological examination, but the number of tissue neutrophils was increased in hyperglycaemic cats (P<0.05). In a retrospective study 14 of 40 (35%) cats with naturally occurring diabetes mellitus had amylase activities below the reference range at the time of admission. Amylase activities normalised within 1 week of insulin therapy and subsequent glycaemic control. Lipase activity was increased in 26 of 40 (65%) diabetic cats and remained elevated despite glycaemic control. In conclusion, hyperglycaemia, but not hyperlipidaemia, increases pancreatic neutrophils in cats. However, because the histological morphology of the exocrine pancreas was normal, hyperglycaemia may play only a minor role in the pathogenesis of pancreatitis. Low amylase activities in diabetic cats may reflect an imbalance in glucose metabolism rather than pancreatitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20132955/