Peer-reviewed veterinary case report
High lipase levels in critically ill dogs with or without pancreatitis
By Prümmer, Julia K et al.·Published in Journal of veterinary internal medicine·2020·Department of Clinical Veterinary Medicine·View original on PubMed →
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Original publication title: Hyperlipasemia in critically ill dogs with and without acute pancreatitis: Prevalence, underlying diseases, predictors, and outcome.
- Species:
- dog
Plain-English summary
A group of critically ill dogs was found to have high levels of lipase, an enzyme that can indicate pancreatitis, but many of these dogs did not actually have this condition. In a study of 1,360 dogs, 16% showed elevated lipase levels at admission, with some having other serious health issues like kidney or immune diseases. Factors like vomiting, abdominal pain, and certain blood test results were linked to higher lipase levels. Unfortunately, dogs with high lipase levels tended to stay in the hospital longer and had a higher risk of death.
People also search for: dog vomiting and abdominal pain · high lipase levels in dogs · critically ill dog treatment · dog kidney disease symptoms · pancreatitis in dogs signs
Abstract
BACKGROUND: Hyperlipasemia is frequent in critically ill people without evidence of acute pancreatitis (AP), and has been associated with increased morbidity and mortality. OBJECTIVE: To evaluate the prevalence of hyperlipasemia at admission and development of hyperlipasemia during hospitalization in critically ill dogs, explore factors associated with hyperlipasemia, and evaluate association with outcome. ANIMALS: Critically ill, client owned dogs (n = 1360), presented on emergency and admitted to the intensive care unit, that had 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester (DGGR) lipase activity measured within 24 hours of admission. METHODS: Retrospective cross-sectional study of clinical and laboratory records. RESULTS: The DGGR lipase activity was increased >3× the upper reference limit at admission in 216/1360 (16%) dogs, of which 70/216 (32%) had a clinical diagnosis of AP. Other primary conditions associated with hyperlipasemia were renal, endocrine, and immune-mediated diseases, and upper airway obstruction. Predictors of hyperlipasemia at admission were prior glucocorticoid administration, vomiting and abdominal pain, increased age, plasma bilirubin and creatinine concentrations, and decreased hematocrit. Of dogs with repeat measurements, 78/345 (23%) had significantly increased lipase during hospitalization, of which 13/78 (17%) had a clinical diagnosis of AP. Other primary conditions associated with in-hospital hyperlipasemia were renal and immune-mediated disorders. Predictors of developing hyperlipasemia during hospitalization were hemodialysis events, increased plasma bilirubin and creatinine concentrations, and decreased hematocrit. Hyperlipasemia both at admission and during hospitalization was associated with longer hospitalization and higher mortality. CONCLUSIONS AND CLINICAL IMPORTANCE: Significant DGGR-hyperlipasemia is frequent in critically ill dogs and associated with a variety of nonpancreatic conditions and negative outcome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32945588/