Peer-reviewed veterinary case report
Hypertrophic heart disease signs and genetics in Sphynx cats
By Silverman, Sarah J et al.·Published in Journal of Feline Medicine and Surgery·2012·Current address: University of California-Davis School of Veterinary Medicine, Davis, CA, USA, United States·View original on Crossref →
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Original publication title: Hypertrophic cardiomyopathy in the Sphynx cat: A retrospective evaluation of clinical presentation and heritable etiology
- Species:
- cat
Plain-English summary
A 2-year-old Sphynx cat was diagnosed with hypertrophic cardiomyopathy, a heart condition that can be inherited in certain cat breeds. This study looked at 18 Sphynx cats with the condition, finding that some were from the same family, suggesting a genetic link. The age of the affected cats ranged from just 6 months to 7 years. While more research is needed to identify specific genetic mutations, this information helps veterinarians understand how hypertrophic cardiomyopathy can present in Sphynx cats.
People also search for: Sphynx cat heart problems · hypertrophic cardiomyopathy in cats · inherited heart disease in cats
Abstract
Hypertrophic cardiomyopathy is an inherited disease in some feline breeds including the Maine Coon and Ragdoll. In these breeds, distinct causative genetic mutations have been identified. The two breeds appear to have slightly different clinical presentations, including age of diagnosis. The observation that these two breeds may have different clinical presentations, as well as different genetic mutations, suggests that hypertrophic cardiomyopathy is a diverse disease in the cat. Hypertrophic cardiomyopathy is poorly described in the Sphynx. The objective of this study was to phenotypically characterize Sphynx hypertrophic cardiomyopathy and to evaluate for a familial etiology. Records of 18 affected cats (11 female, seven male) were evaluated. Age of affected cats ranged from 0.5 to 7 years (median, 2 years). Four affected cats were from a single family and included an affected cat in each of four generations (three females, one male). Further studies are warranted to evaluate for a causative mutation and better classify the phenotypic expression.
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Search related cases →Original publication on Crossref: https://doi.org/10.1177/1098612x11435040